1.新污染物鉴定与分析
2.基于组学技术的环境毒理与健康研究
3.环境污染物暴露对人群的健康效应
1.新污染物鉴定与分析
2.基于组学技术的环境毒理与健康研究
3.环境污染物暴露对人群的健康效应
1.国家自然科学基金委员会,青年科学基金项目,三氯生暴露对小鼠脑部损伤效应的探究,2021-01-01至2023-12-31,25万元,结题,主持;
2.国家自然科学基金委员会,面上项目,全氟化合物通过影响转运蛋白干扰IgG跨胎盘转运的机制研究,2023-01至2026-12,54万元,在研,主持;
3.广州市科技计划项目,基础与应用基础研究项目,整合蛋白质组学和代谢组学探索三氯生暴露对小鼠心脏的损伤机制,2022-04至2024-03,5万元,结题,主持。
(一)论文
[1] Huang, W.; Pan, X.-F.; Tang, S.; Sun, F.; Wu, P.; Yuan, J.; Sun, W.; Pan, A.; Chen, D., Target exposome for characterizing early gestational exposure to contaminants of emerging concern and association with gestational diabetes mellitus. Environmental Science & Technology 2023, 57 (36), 13408–13418.
[2] Sun, F.; Huang, Y.; Chen, H.; Huang, J.; Zhang, L.; Wei, S.; Liu, F.; Chen, D.; Huang, W.*, BPA and its alternatives BPF and BPAF exaggerate hepatic lipid metabolism disorders in male mice fed a high fat diet. Science of the Total Environment 2023, 867, 161521.
[3] Huang, W.; Cao, G.; Deng, C.; Chen, Y.; Wang, T.; Chen, D.; Cai, Z., Adverse effects of triclosan on kidney in mice: Implication of lipid metabolism disorders. Journal of Environmental Sciences 2023, 124, 481-490.
[4] Luo, K.#; Huang, W.#; Zhang, Q.; Liu, X.; Nian, M.; Wei, M.; Wang, Y.; Chen, D.; Chen, X.; Zhang, J., Environmental exposure to legacy poly/perfluoroalkyl substances, emerging alternatives and isomers and semen quality in men: A mixture analysis. Science of the Total Environment 2022, 833, 155158.
[5] Huang, J.; Qi, Y.; Zeng, X.; Huang, W.*; Chen, D., Simultaneous quantification of plasma immunoglobulin subclasses for assessment of maternal and fetal immune response during pregnancy. Journal of Chromatography A 2022, 1673, 463096.
[6] Deng, C.; Huang, J.; Qi, Y.; Chen, D.; Huang, W.*, Distribution patterns of rubber tire-related chemicals with particle size in road and indoor parking lot dust. Science of the Total Environment 2022, 844, 157144.
[7] Huang, W.; Shi, Y.; Huang, J.; Deng, C.; Tang, S.; Liu, X.; Chen, D., Occurrence of substituted p-phenylenediamine antioxidants in dusts. Environmental Science & Technology Letters 2021, 8 (5), 381-385.
[8] Huang, W.; Zhu, L.; Zhao, C.; Chen, X.; Cai, Z., Integration of proteomics and metabolomics reveals promotion of proliferation by exposure of bisphenol S in human breast epithelial MCF-10A cells. Science of the Total Environment 2020, 136453.
[9] Huang, W.; Zhao, C.; Zhong, H.; Zhang, S. D.; Xia, Y. J.; Cai, Z. W., Bisphenol S induced epigenetic and transcriptional changes in human breast cancer cell line MCF-7. Environmental Pollution 2019, 246, 697-703.
[10] Huang, W.; Xie, P.; Cai, Z., Lipid metabolism disorders contribute to hepatotoxicity of triclosan in mice. Journal of Hazardous Materials 2019, 384, 121310.
(二)奖励
1.2017年,“香江学者奖”
2.2022年,广东省珠江人才计划“青年拔尖人才”
本科生课程:《环境影响评价》《环境影响评价课程设计》
隶属于“暴露与代谢组学研究”团队,主要应用基于质谱的暴露组学、代谢组学及蛋白质组学等技术,针对高效精准表征新污染物环境暴露与疾病健康风险这一需求,从构建筛查技术—揭示暴露特征—阐明风险机制的思路开展研究。