课题组网页:https://www.x-mol.com/groups/Amy-Lee
1. 二次电喷雾离子源关键技术及装置研发
2. 基于质谱技术的呼气代谢组及呼气生物标志物研究
3. 面向无创检测监测的转化医学及生物医学工程研究
1. 国家自然科学基金委员会,优秀青年科学基金项目,环境分析化学,2022-01至2024-12,200万元,在研;
2. 广东省科学技术厅,广东省基础与应用基础研究重大项目(基石)项目,重疾呼气无创智能诊断技术的应用基础研究,2024-01至2025-12,500万元,在研;
3. 广东省科学技术厅,广东省国际科技合作项目,高性能二次电喷雾离子源的研制及其在环境与健康领域的应用,2022-01至2024-12,100万元,在研;
4. 国家自然科学基金委员会,重大研究计划培育项目,基于人体吸入和呼出气中颗粒物粒径谱和成分谱无损、实时分析的大气细颗粒物暴露评价新方法研究,2016-01至2018-12,88.8万元,已结题;
5. 国家科技部,重点专项课题,移动污染源VOCs排放快速在线监测技术研发,2016-07至2020-07,724万元,已结题;
6. 广东特支计划,科技创新青年拔尖人才,人体呼气代谢组直接质谱精准识别系统研发,2017-07至2020-06,30万元,已结题。
(一)论文
1. Hui Huang, Jianming Yang, Chen Tao, Ligang Hu, Tao Huan, Wei Zhang, Keda Zhang*, Xue Li*. Exhaled breath analysis of non-volatile drugs, Towards clinical applications. TrAC Trends in Analytical Chemistry, 2024, 171, 177541.
2. Lei Li, Anthony S. Wexler, Xue Li*, Ligang Hu*, Guibin Jiang. In situ characterization of bioaerosols at the single-particle level using single-particle mass spectrometry, a promising tool for defending human health against bioaerosol transmission. Analytical Chemistry, 2023, 95(29), 10839–10843.
3. Huifan Deng†, Xin Xu†, Kangyi Wang, Jinli Xu, Gwendal Loisel, Yiqun Wang, Hongwei Pang, Pan Li, Zebin Mai, Shi-Chao Yan, Xue Li*, Sasho Gligorovski*. The effect of human occupancy on indoor air quality through real-time measurements of key pollutants. Environment Science & Technology, 2022, 56(22), 15377–15388.
4. Xing Chen†, Keda Zhang†, Zhihong Yin, Mingliang Fang, Weidan Pu, Zhening Liu, Lei Li, Pablo Sinues, Robert Dallmann, Zhen Zhou, Xue Li*. Online real-time monitoring of exhaled breath particles reveals unnoticed transport of non-volatile drugs from blood to breath. Analytical Chemistry, 2021, 93, 12, 5005–5008.
5. Huifan Deng, Jiangpin Liu, Yiqun Wang, Wei Song, Xinming Wang, Xue Li*, Davide Vione, Sasho Gligorovski*. Effect of inorganic salts on N-containing organic compounds formed by heterogeneous reaction of NO2 with oleic acid. Environmental Science & Technology, 2021, 55(12), 7831–7840.
6. Jiafa Zeng†, Majda Mekic†, Xin Xu, Gwendal Loisel, Zhen Zhou, Sasho Gligorovski*, Xue Li*. A novel insight into the ozone-skin lipids oxidation products observed by secondary electrospray ionization high resolution mass spectrometry. Environmental Science & Technology, 2020, 54(21), 13478–13487.
7. Jiafa Zeng†, Zhujun Yu†, Majda Mekic†, Jiangping Liu, Sheng Li, Gwendal Loisel, Wei Gao, Adrien Gandolfo, Zhen Zhou, Xinming Wang, Hartmut Herrmann, Sasho Gligorovski*, Xue Li*. Evolution of indoor cooking emissions captured by using secondary electrospray ionization high resolution mass spectrometry. Environmental Science & Technology Letters, 2020, 7(2), 76–81.
8. Xue Li*. Editorial of special issue on bridging aerosol chemistry and health impact. Science of the Total Environment, 2020, 713, 136699.
9. Sasho Gligorovski*, Xue Li*, Hartmut Herrmann. Indoor(photo) chemistry in China and resulting health impact. Environmental Science & Technology, 2018, 52(19), 10909–10910.
10. Xue Li*, Sasho Gligorovski*, Hartmut Herrmann. Underestimated contribution of HONO to indoor OH radicals: an emerging concern. Science Bulletin, 2018, 63(21), 1383-1384.
11. Xue Li†, Pablo Martínez-Lozano Sinues†, Robert Dallmann†, Lukas Bregy, Maija Hollmén, Steven Proulx, Steven A. Brown, Michael Detmar, Malcolm Kohler, Renato Zenobi*. Drug pharmacokinetics determined by real-time analysis of mouse breath. Angewandte Chemie International Edition, 2015, 54(27), 7815–7818.
12. Xue Li*, Renato Zenobi*. Use of polyetheretherketone as a material for solid phase extraction of hydroxylated metabolites of polycyclic aromatic hydrocarbons in human urine. Analytical Chemistry, 2013, 85, 3526–3531.
13. Xue Li†, Bin Hu†, Jianhua Ding, Huanwen Chen*. Rapid characterization of complex viscous samples at molecular levels by neutral desorption extractive electrospray ionization mass spectrometry. Nature Protocols, 2011, 6, 1010–1025.
(二)专利
1. 李雪,尹志红,陈星,方明亮,帕布罗·辛纽斯. 一种生物气体样品中醛酮类物质的采集方法、分析方法及其装置. 授权日期:2023.09.12. 专利号:ZL202110107936.4.
2. X.Li, Michael J. Xu. Method of collaboration between two multi-channel sampling devices. 授权日期:2022.10.25. 专利号(英国):GB2604083.
3. X.Li, Michael J. Xu, Z.Yin. Multi-channel gas sampling and detecting device with interval gas supply. 授权日期:2022.6.14. 专利号(英国):GB2587579.
4 X.Li, Michael J. Xu. Multi-channel sampling and detection device. 授权日期:2022.12.19. 专利号(英国):GB2604084.
5. 叶枫,张志娟,李征途,李雪,王彤,严秀英,周振,高伟. 马尔尼菲篮状菌病诊断的特征物及其筛选方法和应用. 授权日期:2020.09.10. 专利号:ZL 202010952586.7.
6. 李雪,斯林尼瓦苏卢∙乌达甘德拉,黄磊,黄正旭,周振,帕布罗·马丁内斯·洛萨诺辛纽斯,高伟,李磊. 一种亚微米气溶胶化学组成的实时、在线快速质谱分析系统与方法. 授权日期:2018.05.15. 专利号:ZL201510150678.2.
7. 古颖纲,王伯光,李雪,周振. 垃圾填埋排放恶臭有机物的直接质谱分析方法. 授权日期:2017.02.22. 专利号:ZL2014-1-0421829.9.
8 方小伟,李雪,于志强,盛国英,傅家谟,陈焕文. 同位素稀释电喷雾萃取电离串联质谱快速检测尿肌酐的分析方法. 授权日期:2014.07.09. 专利号:ZL201210191971.X.
9 李雪,陈焕文,李银萍,方小伟,于志强,盛国英,傅家谟. 电喷雾萃取电离串联质谱快速检测尿中1-OHP的方法. 申请日期:2014.12.31. 专利号:ZL201210188912.7.
10. 黄俊,王泰,李雪,余刚,邓述波. 检测船舶防污漆中滴滴涕组分的分析方法. 授权日期:2011.08.17. 专利号:ZL200810240262.X.
(三)奖励
1. 2023年中华医学会医学科学技术奖二等奖,排名:6/6;
2. 2022年中国环境科学学会最美科技工作者奖;
3. 2021年广东省环境科学学会生态环境青年科技优秀奖;
4. 2019年中国环境科学学会室内环境与健康分会何兴舟室内环境与健康青年学术奖;
5. 2019年中国化学会青年环境化学奖;
6. 2016年中国环境科学学会优秀环境科技工作者奖;
7. 2015年中国仪器仪表学会科学技术奖一等奖,排名:7/10;
8. 2014年国家科技部创新人才推进计划-重点领域创新团队核心成员;
9. 2012年中国环境科学学会青年科技奖。
硕士研究生课程:《质谱应用》、《有机质谱应用》
博士研究生课程:《有机质谱应用》
课题组网页:https://www.x-mol.com/groups/Amy-Lee