1. 呼气代谢组分析方法研究及其在临床诊断、治疗监测中的应用

2. 蛋白组学分析方法的研究及其在环境污染物毒理机制方面的应用

（一）论文

1. Xing Chen1, Xiaolan Hu¹, Xieguang Zhang¹, Hui Huang, Heng Meng, Jianming Yang, Chen Tao, Wei Zhang, Xue Li, Keda Zhang. Breath analysis: Harnessing its potential for non-volatile drug caffeine monitoring in human body. Microchemical Journal, 2024: 110130. (Co-first author)

2. Xiaolan Hu, Shilin Gong, Quan He, Jian-Lin Wu*, and Na Li^*. Less is more: A new perspective for toxicity of emerging contaminants by structures, protein adducts and proteomics. TrAC Trends in Analytical Chemistry, 2023, 117289.

3. Xiaolan Hu, Jian-Lin Wu^*, Wen Miao, Fei Long, Hudan Pan, Tao Peng, Xiaojun Yao, and Na Li^*. Covalent Protein Modification: An Unignorable Factor for Bisphenol A-induced Hepatotoxicity. Environmental Science & Technology,2022, 56, 9536−9545.

4. Shilin Gong¹, Xiaolan Hu¹, Shengshuang Chen, Baoqing Sun, Jian-Lin Wu*, Na Li*. Dual roles of drug or its metabolite-protein conjugate (DMPC): cutting-edge strategy of drug discovery using shotgun proteomics. Medicinal Research Reviews, 2022,42:1704-1734. (Co-first author)

5. Xiaolan Hu¹, Xiqing Bian¹, Wan-Yi Gu, Baoqing Sun, Xiang Gao, Jian-Lin Wu*, Na Li*. Stand out from matrix: Ultra-sensitive LC-MS/MS method for determination of histamine in complex biological samples using derivatization and solid phase extraction. Talanta, 2021, 225, 122056.

6. Xiaolan Hu, Xi-Qing Bian, Xin Wu, Jian-Yong Li, Hui-Ming Hua, Yue-Hu Pei, Ai-Hong Han, Jiao Bai*. Penioxalamine A, a novel prenylated spiro-oxindole alkaloid from Penicillium oxalicum TW01-1. Tetrahedron Letters, 2014, 55(29): 3864-3867.

7. Yue Zhuo, Yida Zhang, Meng Li, Haiying Wu, Shilin Gong, Xiaolan Hu, Yu Fu, Xinzi Shen, Baoqing Sun, Jian-Lin Wu, Na Li*. Drug Hepatotoxic Evaluation via Biomarker Quantification and Pathway Mapping of Large-Scale Chemical Proteomics. Food and Chemical Toxicology, 2021, 153, 112257.

8. Shilin Gong, Yue Zhuo, Shengshuang Chen, Xiaolan Hu, Xing-xing Fan, Jian-Lin Wu*, Na Li*. Quantification of Osimertinib and Metabolite-Protein Modification Reveals Its High Potency and Long Duration of Effects on Target Organs. Chemical research in toxicology, 2021, 34(11), 2309–2318.

9. Sajad Fakhri, Merve Tomas, Esra Capanoglu, Yaseen Hussain, Fatemeh Abbaszadeh, Baiyi Lu, Xiaolan Hu, Jian-Lin Wu, Liang Zou, Antonella Smeriglio, Jesus Simal-Gandara, Hui Cao, Jianbo Xiao*, Haroon Khan*. Antioxidant and anticancer potentials of edible flowers: where do we stand? Critical reviews in food science and nutrition, 2021,1–57.

10. Xiao-Cui Zhuang, Yong-Li Zhang, Gui-Lin Chen, Ye Liu, Xiaolan Hu, Na Li, Jian-Lin Wu, Ming-Quan Guo*. Identification of Anti-Inflammatory and Anti-Proliferative Neolignanamides from Warburgia ugandensis Employing Multi-Target Affinity Ultrafiltration and LC-MS. Pharmaceuticals (Basel, Switzerland), 2021, 14(4), 313.

11. Xiqing Bian, Jiao Bai*, Xiaolan Hu, Xin Wu, Chunmei Xue, Aihong Han, Guangyue Su, Huiming Hua, Yuehu Pei. Penioxalicin, a novel 3-nor-2, 3-seco-labdane type diterpene from the fungus Penicillium oxalicum TW01-1. Tetrahedron letters, 2015, 56(35): 5013-5016.

12. Xiao-Lei Zhou, Jiu-Hong WU*, Jiao Bai, Xiaolan Hu, En-Zhen LI, Ning SHI, Yue-Hu PEI. A new aristolactam alkaloid from the stems of Dasymaschalon trichophorum. Chinese Journal of Natural Medicines, 2013, 11(1): 81-83.

（二）专利

1. 裴月湖，白皎，陈刚，胡晓兰。双四氢苯并吡喃酮二聚体类化合物在抗癌药物中的应用，发明专利，专利申请号： 201110332660.6

2. 李娜，伍建林，胡晓兰。 一种筛选潜在共价药物的方法, 澳门科技大学，发明专利，202310372589.7.

研究生课程：《质谱应用》

研究团队专注于两个前沿的科学领域：呼气代谢组学和蛋白组学分析。在呼气代谢组学方面，致力于创新呼气分析技术的开发与完善，旨在通过精准检测呼出气体中的生物标志物，为临床诊断和治疗药物监测提供新的视角。在蛋白组学分析领域，专注于开发先进的蛋白组学方法，以深入探究环境污染物对人体健康的潜在影响，为环境保护和公共健康提供科学依据。

团队配置有四极杆-静电场轨道阱高分辨质谱、高分辨飞行时间质谱、气相色谱质谱、离子阱质谱，并且配备有高效液相色谱仪、离子色谱仪和气相色谱仪等色谱设备。这些仪器设备为实验分析提供了可靠的研究平台。